Bone Abstracts

Roundabout receptors are crucial regulators of vessels and axons growth during development. A comparative transcriptomic study between the MDA-MB-231 breast cancer cell line and its osteotropic subpopulation, MDA-B02 cells, has shown an overexpression of ROBO4 receptor. Interestingly, a high ROBO4 expression in primary tumour from patients with breast cancer correlates with poor prognosis and increased risk of bone metastasis relapse. Inoculation of ROBO4 depleted cells in the...